Leflunomide is a medicine used to manage rheumatoid arthritis. Suppressing parts of the immune system that overreact prevents long-term joint damage and keeps movement easier.
Leflunomide belongs to a group of drugs known as disease-modifying antirheumatic drugs (DMARDs), which work to slow the damage that arthritis can cause. Leflunomide is the active compound in medicines such as Arava and is taken to help control inflammation and joint discomfort.
Leflunomide is an immunosuppressant, meaning it reduces the activity of parts of your immune system that can mistakenly attack your own joints.
Leflunomide is commonly used to address:
People who experience chronic joint issues and have been advised by a healthcare professional that an immunosuppressant may be appropriate often receive leflunomide as part of their treatment plan.
Leflunomide slows down a key pathway, the production of pyrimidines, which immune cells need to multiply quickly. By limiting this supply, the drug reduces the number of overactive immune cells that cause joint inflammation. The result is less swelling and pain. This effect builds up over several weeks as the body adjusts to the reduced immune activity.
Women who are pregnant, trying to become pregnant, or breastfeeding should avoid this medicine because it can affect a developing baby. People with existing liver problems, severe kidney disease, or a history of frequent infections should discuss alternatives with their healthcare team.
Leflunomide can interact with:
Always read the specific medication's label for the most up-to-date interaction information.
Older adults and people with pre-existing liver disease tend to notice side effects more often. Those taking multiple immune-modulating medicines or who have a history of frequent infections may also be more susceptible. Pregnant women should never use leflunomide because of potential harm to the baby.
Store leflunomide-containing tablets such as Arava at room temperature, away from direct sunlight, moisture, and heat. Keep the bottle tightly closed and out of reach of children. Remember that different brand versions may vary in strength and dosing instructions.
For detailed usage, dosing, and administration, refer to the specific medication's clinical information.
This article provides an educational overview of leflunomide and is not medical advice. Medicines containing this ingredient, such as Arava, may differ in formulation, strength, and directions. The information here does not replace professional clinical judgment, and the writer disclaims any liability for how it is used. Readers should review their specific medication's labeling and seek guidance from a qualified healthcare professional.
