Utilized for herpes simplex infections to alleviate viral growth and support skin lesion healing.
Mechanism of Action
Aciclovir is converted to acyclovir triphosphate by viral thymidine kinase. This active form selectively inhibits viral DNA polymerase and incorporates into viral DNA, causing chain termination.
Route of Administration
Oral
Onset Time
24–48 hours
Duration
3–5 hours (half-life)
Contraindications
Hypersensitivity to acyclovir, Hypersensitivity to valacyclovir
Severe Adverse Events
Renal failure, Neurotoxicity, Anaphylaxis — requires immediate medical attention
Common Side Effects
Nausea, Headache, Vomiting
Uncommon Side Effects
Diarrhea, Dizziness, Fatigue
Drug Interactions
Alcohol, Probenecid, Zidovudine, Tenofovir
Pregnancy Safety Warnings
FDA Category B: No evidence of fetal risk. Breastfeeding: Excreted in milk; compatible with caution.
Age Restrictions
Safety and efficacy established in pediatric patients of all ages.
Storage Guidelines
Store at room temperature and protect from moisture.
Information related to Aciclovir is compiled and periodically reviewed with reference to established medical sources and prescribing guidance. Content is provided for general reference and should be confirmed with a registered healthcare professional before use.
