Utilized for major depressive disorder and smoking cessation to manage mood balance and support tobacco abstinence.
Mechanism of Action
Bupropion inhibits the reuptake of dopamine and norepinephrine in the central nervous system. This increases the synaptic concentrations of these neurotransmitters to regulate mood and diminish nicotine cravings.
Route of Administration
Oral
Onset Time
1–2 weeks
Duration
12–24 hours
Contraindications
Seizure disorder, Bulimia or anorexia nervosa, Concurrent use of MAO inhibitors, Abrupt discontinuation of alcohol or sedatives
Severe Adverse Events
Seizures, Suicidal ideation, Psychosis — requires immediate medical attention
Common Side Effects
Dry mouth, Headache, Insomnia
Uncommon Side Effects
Nausea, Agitation, Weight loss
Drug Interactions
Alcohol, MAO Inhibitors, Ritonavir, Levodopa, Tamoxifen
Pregnancy Safety Warnings
FDA Category C: Benefit must justify risk. Breastfeeding: Excreted in milk; monitor infant.
Age Restrictions
Safety and efficacy in pediatric patients under 18 have not been established.
Information related to Bupropion is compiled and periodically reviewed with reference to established medical sources and prescribing guidance. Content is provided for general reference and should be confirmed with a registered healthcare professional before use.
