Utilized for rheumatoid arthritis to alleviate joint pain and support anti-inflammatory response.
Mechanism of Action
Diclofenac inhibits the cyclooxygenase enzymes (COX-1 and COX-2). This prevents the synthesis of prostaglandins, which are key mediators of pain, inflammation, and fever.
Route of Administration
Oral
Onset Time
30–60 minutes
Duration
8–12 hours
Contraindications
Active peptic ulcer, Severe heart failure, History of asthma with NSAIDs, Coronary artery bypass graft surgery
Severe Adverse Events
Gastrointestinal hemorrhage, Myocardial infarction, Hepatotoxicity — requires immediate medical attention
Common Side Effects
Dyspepsia, Headache, Dizziness
Uncommon Side Effects
Abdominal pain, Constipation, Diarrhea
Drug Interactions
Alcohol, Warfarin, Lithium, Methotrexate, Aspirin
Pregnancy Safety Warnings
FDA Category C/D: Avoid use in third trimester. Breastfeeding: Excreted in milk; compatible with caution.
Age Restrictions
Safety and efficacy in pediatric patients have not been established.
Information related to Diclofenac is compiled and periodically reviewed with reference to established medical sources and prescribing guidance. Content is provided for general reference and should be confirmed with a registered healthcare professional before use.
