Utilized for alcohol dependence to manage abstinence and support long-term behavioral recovery.
Mechanism of Action
Disulfiram irreversibly inhibits the enzyme aldehyde dehydrogenase. If alcohol is consumed, acetaldehyde accumulates in the blood, causing a highly unpleasant physiological reaction (flushing, nausea, tachycardia) that acts as a deterrent.
Route of Administration
Oral
Onset Time
12 hours
Duration
1–2 weeks (irreversible effect)
Contraindications
Recent alcohol consumption, Severe heart disease, Psychosis, Concurrent use of metronidazole
Severe Adverse Events
Hepatotoxicity, Psychotic reaction, Severe cardiovascular collapse — requires immediate medical attention
Information related to Disulfiram is compiled and periodically reviewed with reference to established medical sources and prescribing guidance. Content is provided for general reference and should be confirmed with a registered healthcare professional before use.
