Indicated for major depressive disorder and neuropathic pain to manage emotional health and support physical comfort.
Mechanism of Action
Duloxetine potentates serotonergic and noradrenergic activity in the central nervous system by inhibiting their reuptake. This increases the activity of descending pain inhibitory pathways as well as regulating mood and anxiety.
Route of Administration
Oral
Onset Time
2–4 weeks
Duration
12 hours (half-life)
Contraindications
Concurrent use of MAO inhibitors, Uncontrolled narrow-angle glaucoma, Severe renal or hepatic impairment
Severe Adverse Events
Serotonin syndrome, Hepatotoxicity, Suicidal ideation — requires immediate medical attention
Common Side Effects
Nausea, Dry mouth, Somnolence
Uncommon Side Effects
Fatigue, Insomnia, Constipation
Drug Interactions
Alcohol, MAO Inhibitors, Warfarin, Tramadol, Ciprofloxacin
Pregnancy Safety Warnings
FDA Category C: Use with caution. Breastfeeding: Excreted in milk; monitor infant.
Age Restrictions
Safety and efficacy established in pediatric patients seven years and older for GAD.
Information related to Duloxetine is compiled and periodically reviewed with reference to established medical sources and prescribing guidance. Content is provided for general reference and should be confirmed with a registered healthcare professional before use.
