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Entresto
Entresto

1.79
This combination compound helps with vasodilation and moderates neurohormonal pathways involved in heart function.
Ingredients
Sacubitril, Valsartan
Category
Heart & Blood Pressure
Availability
In Stock
Delivery Time
Airmail (14-21 days) | Trackable (5-9 days)
Shipped in a discreet, unmarked envelope with all required documents enclosed.

Product Sheet

Active Ingredient(s)
Sacubitril, Valsartan
Reference Brand
Sacubitril/Valsartan
Product Origin
Generic Alternative
Reference Manufacturer
Novartis
Product Form
Tablet
Regulatory Classification
Rx
Primary Category
Heart & Blood Pressure
Product Category
Angiotensin Receptor-Neprilysin Inhibitor (ARNI)
Pharmacological Class
Cardiovascular Combination
Clinical Indications
Chronic heart failure
Manufacturer Description
Developed for chronic heart failure to manage cardiac load and support improved survival outcomes.
Mechanism of Action
Sacubitril inhibits neprilysin, increasing levels of beneficial natriuretic peptides. Valsartan blocks the AT1 receptor to inhibit the harmful effects of angiotensin II. Together, they promote vasodilation and reduce fluid retention.
Route of Administration
Oral
Onset Time
1–2 weeks
Duration
12–24 hours
Contraindications
History of angioedema with ACEIs or ARBs, Concurrent use of ACE inhibitors, Pregnancy, Severe hepatic impairment
Severe Adverse Events
Angioedema, Renal failure, Fetal toxicity — requires immediate medical attention
Common Side Effects
Dizziness, Cough, Fatigue
Uncommon Side Effects
Hypotension, Hyperkalemia, Increased creatinine
Drug Interactions
Alcohol, ACE Inhibitors, Lithium, Potassium Supplements, NSAIDs
Pregnancy Safety Warnings
FDA Category D: High risk of fetal death or injury. Breastfeeding: Not recommended.
Age Restrictions
Safety and efficacy established in pediatric patients one year and older.
Storage Guidelines
Store at room temperature away from moisture.
Related Products
Diovan, Enrest
Information related to Entresto is compiled and periodically reviewed with reference to established medical sources and prescribing guidance. Content is provided for general reference and should be confirmed with a registered healthcare professional before use.
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