Utilized for adrenal insufficiency to manage sodium balance and support blood pressure maintenance.
Mechanism of Action
Fludrocortisone is a powerful mineralocorticoid. It increases sodium reabsorption and potassium excretion in the renal distal tubules, effectively increasing extracellular fluid volume and regulating electrolyte balance in deficient states.
Route of Administration
Oral
Onset Time
12–24 hours
Duration
24–36 hours
Contraindications
Systemic fungal infections, Hypersensitivity to fludrocortisone
Severe Adverse Events
Congestive heart failure, Seizures, Anaphylaxis — requires immediate medical attention
Common Side Effects
Headache, Dizziness, Stomach upset
Uncommon Side Effects
Hypertension, Edema, Hypokalemia
Drug Interactions
Alcohol, Digoxin, Diuretics, Aspirin, Phenytoin
Pregnancy Safety Warnings
FDA Category C: Use only if clearly needed. Breastfeeding: Excreted in milk; monitor infant.
Age Restrictions
Safety and efficacy established in pediatric patients; monitor growth.
Information related to Fludrocortisone is compiled and periodically reviewed with reference to established medical sources and prescribing guidance. Content is provided for general reference and should be confirmed with a registered healthcare professional before use.
