Utilized for erectile dysfunction and premature ejaculation to manage blood flow and support timing regulation.
Mechanism of Action
Sildenafil inhibits PDE5 to promote penile blood flow. Duloxetine inhibits the reuptake of serotonin and norepinephrine, modulating the ejaculatory reflex and enhancing mood stability.
Route of Administration
Oral
Onset Time
1–2 hours
Duration
6–12 hours
Contraindications
Concurrent use of nitrates, Concurrent use of MAO inhibitors, Uncontrolled glaucoma, Severe heart disease
Severe Adverse Events
Serotonin syndrome, Priapism, Suicidal ideation — requires immediate medical attention
Common Side Effects
Headache, Nausea, Dry mouth
Uncommon Side Effects
Insomnia, Dizziness, Sweating
Drug Interactions
Nitrates, Alcohol, MAO Inhibitors, Grapefruit, Warfarin
Pregnancy Safety Warnings
FDA Category C: Not applicable. Breastfeeding: Not applicable.
Information related to Malegra DXT is compiled and periodically reviewed with reference to established medical sources and prescribing guidance. Content is provided for general reference and should be confirmed with a registered healthcare professional before use.
