Utilized for erectile dysfunction and premature ejaculation to manage physiological arousal and support ejaculatory control.
Mechanism of Action
Sildenafil inhibits PDE5 to enable blood inflow for an erection. Fluoxetine inhibits serotonin reuptake, increasing synaptic serotonin levels to delay the ejaculation reflex through spinal cord modulation.
Route of Administration
Oral
Onset Time
1–3 hours
Duration
12–24 hours
Contraindications
Concurrent use of nitrates, Concurrent use of MAO inhibitors, Severe hepatic impairment, Bipolar disorder
Severe Adverse Events
Serotonin syndrome, Priapism, Suicidal ideation — requires immediate medical attention
Common Side Effects
Nausea, Headache, Nervousness
Uncommon Side Effects
Insomnia, Flushing, Dizziness
Drug Interactions
Nitrates, Alcohol, MAO Inhibitors, Tramadol, Warfarin
Pregnancy Safety Warnings
FDA Category C: Not applicable. Breastfeeding: Not applicable.
Information related to Malegra FXT is compiled and periodically reviewed with reference to established medical sources and prescribing guidance. Content is provided for general reference and should be confirmed with a registered healthcare professional before use.
