Indicated for major depressive disorder and social anxiety disorder to manage emotional regulation and support symptom relief.
Mechanism of Action
Paroxetine selectively inhibits the reuptake of serotonin (5-HT) at the presynaptic membrane, increasing its availability in the synaptic cleft to enhance serotonergic neurotransmission.
Route of Administration
Oral
Onset Time
2–4 weeks
Duration
21 hours
Contraindications
Concurrent use of MAO inhibitors, Concurrent use of thioridazine, Hypersensitivity to paroxetine
Severe Adverse Events
Serotonin syndrome, Suicidal ideation, Hyponatremia — requires immediate medical attention
Common Side Effects
Nausea, Somnolence, Sweating
Uncommon Side Effects
Sexual dysfunction, Dry mouth, Insomnia
Drug Interactions
MAO Inhibitors, Warfarin, Alcohol, Tramadol, St. John's Wort
Pregnancy Safety Warnings
FDA Category D: High risk of congenital malformations. Breastfeeding: Excreted in milk; monitor infant for sedation.
Age Restrictions
Not recommended for pediatric use under 18 years of age.
Information related to Paxil is compiled and periodically reviewed with reference to established medical sources and prescribing guidance. Content is provided for general reference and should be confirmed with a registered healthcare professional before use.
