Indicated for organ transplant rejection prophylaxis to target immune response and support graft survival.
Mechanism of Action
Tacrolimus inhibits T-lymphocyte activation by binding to intracellular protein FKBP-12. This complex inhibits calcineurin, preventing the dephosphorylation and translocation of nuclear factor of activated T-cells, thus blocking cytokine production.
Route of Administration
Oral
Onset Time
1–3 days
Duration
12–24 hours
Contraindications
Hypersensitivity to tacrolimus, Concurrent use of live vaccines, Hypersensitivity to polyoxyl hydrogenated castor oil
Severe Adverse Events
Nephrotoxicity, Neurotoxicity, Lymphoma — requires immediate medical attention
Information related to Prograf is compiled and periodically reviewed with reference to established medical sources and prescribing guidance. Content is provided for general reference and should be confirmed with a registered healthcare professional before use.
