Intended for amenorrhea to manage hormonal balance and support endometrial protection during estrogen therapy.
Mechanism of Action
Progesterone transforms a proliferative endometrium into a secretory one. It inhibits pituitary gonadotropin secretion to prevent ovulation and induces maturation of the uterine lining.
Route of Administration
Oral
Onset Time
1–3 days
Duration
24 hours
Contraindications
History of thromboembolic disorders, Breast cancer, Missed abortion, Liver disease
Severe Adverse Events
Deep vein thrombosis, Pulmonary embolism, Vision loss — requires immediate medical attention
Common Side Effects
Headache, Nausea, Breast tenderness
Uncommon Side Effects
Dizziness, Mood changes, Abdominal cramping
Drug Interactions
Alcohol, Ketoconazole, Rifampin, St. John's Wort, Phenobarbital
Pregnancy Safety Warnings
FDA Category B: No evidence of fetal risk. Breastfeeding: Excreted in milk; monitor infant.
Age Restrictions
Safety and efficacy in pediatric patients have not been established.
Information related to Prometrium is compiled and periodically reviewed with reference to established medical sources and prescribing guidance. Content is provided for general reference and should be confirmed with a registered healthcare professional before use.
