Utilized for pulmonary arterial hypertension to manage pulmonary resistance and support cardiovascular endurance.
Mechanism of Action
Sildenafil inhibits PDE5 in pulmonary vascular smooth muscle. This leads to increased cGMP levels, promoting relaxation of the pulmonary arteries and reducing pulmonary vascular pressure.
Route of Administration
Oral
Onset Time
1 hour
Duration
4–6 hours
Contraindications
Concurrent use of nitrates, Hypersensitivity to sildenafil, Severe cardiovascular disease
Information related to Revatio is compiled and periodically reviewed with reference to established medical sources and prescribing guidance. Content is provided for general reference and should be confirmed with a registered healthcare professional before use.
