Utilized for hiv-1 and hepatitis b to manage viral replication and support immune system preservation.
Mechanism of Action
Tenofovir is a nucleotide analogue that inhibits viral reverse transcriptase and HBV polymerase. It competes with the natural substrate deoxyadenosine 5'-triphosphate, leading to DNA chain termination and blocking of the viral replication cycle.
Route of Administration
Oral
Onset Time
2–4 weeks
Duration
17 hours (half-life)
Contraindications
Severe renal impairment, Hypersensitivity to tenofovir
Severe Adverse Events
Lactic acidosis, Renal failure, Hepatitis b exacerbation — requires immediate medical attention
Information related to Tenofovir is compiled and periodically reviewed with reference to established medical sources and prescribing guidance. Content is provided for general reference and should be confirmed with a registered healthcare professional before use.
