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Tolvaptan
Tolvaptan

5.02
Works on the kidneys to regulate water excretion and manage fluid balance in the heart and circulatory system.
Ingredient
Tolvaptan
Category
Hormone Therapy
Availability
In Stock
Delivery Time
Airmail (14-21 days) | Trackable (5-9 days)
Shipped in a discreet, unmarked envelope with all required documents enclosed.

Product Sheet

Active Ingredient(s)
Tolvaptan
Reference Brand
Samsca
Product Origin
Generic Product
Reference Manufacturer
Otsuka Pharmaceutical
Product Form
Tablet
Regulatory Classification
Rx
Primary Category
Hormones
Product Category
Vasopressin Receptor Antagonist
Pharmacological Class
Vaptans
Manufacturer Description
Indicated for hyponatremia and polycystic kidney disease to manage fluid balance and support electrolyte stability.
Mechanism of Action
Tolvaptan is a selective vasopressin V2-receptor antagonist. It prevents vasopressin from binding to its receptor in the renal collecting ducts, leading to the excretion of free water without affecting sodium or potassium levels.
Route of Administration
Oral
Onset Time
2–4 hours
Duration
24 hours
Contraindications
Hypovolemic hyponatremia, Concurrent use of strong CYP3A inhibitors, Inability to sense or respond to thirst, Hypersensitivity to tolvaptan
Severe Adverse Events
Hepatotoxicity, Osmotic demyelination syndrome, Anaphylaxis — requires immediate medical attention
Common Side Effects
Thirst, Dry mouth, Frequent urination
Uncommon Side Effects
Nausea, Constipation, Hypernatremia
Drug Interactions
Alcohol, Ketoconazole, Rifampin, Digoxin, Grapefruit
Pregnancy Safety Warnings
FDA Category C: Use only if clearly needed. Breastfeeding: Not recommended.
Age Restrictions
Safety and efficacy in pediatric patients have not been established.
Storage Guidelines
Store at room temperature in a dry place.
Related Products
Jinarc, Samsca
Information related to Tolvaptan is compiled and periodically reviewed with reference to established medical sources and prescribing guidance. Content is provided for general reference and should be confirmed with a registered healthcare professional before use.
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