Formulated for acne vulgaris to manage skin cell turnover and support lesion reduction.
Mechanism of Action
Tretinoin binds to retinoic acid receptors, modifying gene expression. This increases follicular epithelial cell turnover and reduces the cohesiveness of keratinocytes, facilitating the expulsion of comedones.
Route of Administration
Topical
Onset Time
2–4 weeks
Duration
24 hours
Contraindications
Hypersensitivity to retinoids, Sunburn, Pregnancy
Severe Adverse Events
Severe skin ulceration, Contact dermatitis, Angioedema — requires immediate medical attention
Common Side Effects
Skin peeling, Dryness, Redness
Uncommon Side Effects
Stinging, Photosensitivity, Pruritus
Drug Interactions
Alcohol, Benzoyl Peroxide, Salicylic Acid, Sulfur
Pregnancy Safety Warnings
FDA Category C: Potential risk in high doses. Use during pregnancy is not recommended. Breastfeeding: Compatible with caution.
Age Restrictions
Safety and efficacy established in pediatric patients 12 years and older.
Information related to Tretinoin Cream is compiled and periodically reviewed with reference to established medical sources and prescribing guidance. Content is provided for general reference and should be confirmed with a registered healthcare professional before use.
