Formulated for insomnia to manage sleep onset and support restful night patterns.
Mechanism of Action
Zaleplon selectively binds to the omega-1 receptor on the GABA-A receptor complex. This action modulates the receptor to enhance the inhibitory effect of GABA, specifically facilitating the rapid induction of sleep.
Route of Administration
Oral
Onset Time
15–20 minutes
Duration
4 hours
Contraindications
Severe hepatic impairment, Hypersensitivity to zaleplon, Severe sleep apnea
Severe Adverse Events
Complex sleep behaviors, Anaphylaxis, Amnesia — requires immediate medical attention
Common Side Effects
Drowsiness, Dizziness, Headache
Uncommon Side Effects
Nausea, Abdominal pain, Paresthesia
Drug Interactions
Alcohol, Cimetidine, Rifampin, Promethazine
Pregnancy Safety Warnings
FDA Category C: Use only if clearly needed. Breastfeeding: Excreted in milk; monitor infant.
Age Restrictions
Safety and efficacy in pediatric patients have not been established.
Information related to Zaleplon is compiled and periodically reviewed with reference to established medical sources and prescribing guidance. Content is provided for general reference and should be confirmed with a registered healthcare professional before use.
