Utilized for erectile dysfunction to alleviate physical barriers and support blood flow targeting.
Mechanism of Action
Sildenafil competitively inhibits the PDE5 enzyme, preventing the breakdown of cGMP. Elevated cGMP levels cause smooth muscle relaxation in the corpus cavernosum, facilitating an erection.
Route of Administration
Oral
Onset Time
30–60 minutes
Duration
4–6 hours
Contraindications
Concurrent use of nitrates, Hypersensitivity to sildenafil
Severe Adverse Events
Priapism, Sudden loss of vision, Myocardial infarction — requires immediate medical attention
Common Side Effects
Headache, Flushing, Nausea
Uncommon Side Effects
Nasal congestion, Dizziness, Dyspepsia
Drug Interactions
Alcohol, Nitroglycerin, Grapefruit, Ketoconazole
Pregnancy Safety Warnings
FDA Category B: No evidence of fetal risk. Breastfeeding: Not applicable.
Information related to Zenegra is compiled and periodically reviewed with reference to established medical sources and prescribing guidance. Content is provided for general reference and should be confirmed with a registered healthcare professional before use.
