Utilized for pulmonary arterial hypertension to manage arterial resistance and support cardiovascular endurance.
Mechanism of Action
Sildenafil inhibits the PDE5 enzyme in the pulmonary vasculature. This increases cGMP levels, promoting relaxation of pulmonary arterial smooth muscle and decreasing pulmonary blood pressure.
Route of Administration
Oral
Onset Time
1 hour
Duration
4–6 hours
Contraindications
Concurrent use of nitrates, Severe heart disease, Hypersensitivity to sildenafil
Information related to Assurans is compiled and periodically reviewed with reference to established medical sources and prescribing guidance. Content is provided for general reference and should be confirmed with a registered healthcare professional before use.
