Formulated for endometriosis and amenorrhea to manage hormonal balance and support menstrual regulation.
Mechanism of Action
Norethindrone transforms a proliferative endometrium into a secretory one. It inhibits the secretion of pituitary gonadotropins, which prevents follicular maturation and ovulation.
Route of Administration
Oral
Onset Time
1–2 days
Duration
24 hours
Contraindications
Pregnancy, Breast cancer, Thromboembolic disorders, Liver disease
Severe Adverse Events
Pulmonary embolism, Stroke, Myocardial infarction — requires immediate medical attention
Common Side Effects
Nausea, Headache, Breakthrough bleeding
Uncommon Side Effects
Breast tenderness, Weight gain, Acne
Drug Interactions
Alcohol, Rifampin, Tobacco, St. John's Wort, Phenytoin
Pregnancy Safety Warnings
FDA Category X: Contraindicated during pregnancy. Breastfeeding: Excreted in milk; monitor infant for jaundice.
Age Restrictions
Clinically recognized for use in post-menarcheal females.
Information related to Aygestin is compiled and periodically reviewed with reference to established medical sources and prescribing guidance. Content is provided for general reference and should be confirmed with a registered healthcare professional before use.
