Indicated for glaucoma to manage ocular pressure and support vision preservation.
Mechanism of Action
Brimonidine reduces aqueous humor production and increases uveoscleral outflow. Timolol blocks beta receptors to decrease humor secretion. Together, they provide superior pressure reduction compared to either drug alone.
Route of Administration
Ophthalmic
Onset Time
1–2 hours
Duration
12–24 hours
Contraindications
Bronchial asthma, Sinus bradycardia, Severe heart failure, Concurrent use of MAO inhibitors
Severe Adverse Events
Bronchospasm, Severe hypotension, Anaphylaxis — requires immediate medical attention
Information related to Combigan is compiled and periodically reviewed with reference to established medical sources and prescribing guidance. Content is provided for general reference and should be confirmed with a registered healthcare professional before use.
