Utilized for allergic reactions to alleviate symptomatic itching and support immune comfort.
Mechanism of Action
Cyproheptadine is a potent antagonist at H1 histamine and serotonin 5-HT2 receptors. Its antihistaminic activity reduces allergy symptoms, while its antiserotonergic activity can stimulate appetite through hypothalamic modulation.
Route of Administration
Oral
Onset Time
30–60 minutes
Duration
4–8 hours
Contraindications
Narrow-angle glaucoma, Concurrent use of MAO inhibitors, Prostatic hypertrophy, Hypersensitivity to cyproheptadine
Severe Adverse Events
Anaphylaxis, Seizures, Agranulocytosis — requires immediate medical attention
Common Side Effects
Somnolence, Dry mouth, Increased appetite
Uncommon Side Effects
Dizziness, Nausea, Weight gain
Drug Interactions
Alcohol, MAO Inhibitors, Amitriptyline, Lorazepam
Pregnancy Safety Warnings
FDA Category B: No evidence of fetal risk. Breastfeeding: Excreted in milk; monitor infant.
Age Restrictions
Safety and efficacy established in pediatric patients two years and older.
Information related to Cyproheptadine is compiled and periodically reviewed with reference to established medical sources and prescribing guidance. Content is provided for general reference and should be confirmed with a registered healthcare professional before use.
