Utilized for shingles and herpes infections to manage viral growth and support skin lesion resolution.
Mechanism of Action
Famciclovir is rapidly converted into penciclovir, which inhibits viral DNA polymerase. This interrupts viral DNA replication and prevents the proliferation of herpes viruses within the host cells.
Route of Administration
Oral
Onset Time
24–48 hours
Duration
2 hours (half-life of active drug)
Contraindications
Hypersensitivity to famciclovir, Hypersensitivity to penciclovir
Severe Adverse Events
Renal failure, Confusion, Anaphylaxis — requires immediate medical attention
Common Side Effects
Headache, Nausea, Diarrhea
Uncommon Side Effects
Fatigue, Dizziness, Abdominal pain
Drug Interactions
Alcohol, Probenecid, Digoxin
Pregnancy Safety Warnings
FDA Category B: No evidence of fetal risk. Breastfeeding: Excreted in milk; monitor infant.
Age Restrictions
Safety and efficacy in pediatric patients have not been established.
Information related to Famciclovir is compiled and periodically reviewed with reference to established medical sources and prescribing guidance. Content is provided for general reference and should be confirmed with a registered healthcare professional before use.
