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Nintedanib
Nintedanib

3.71
Components inhibit pathways that trigger fibrotic changes in lung tissue.
Ingredient
Nintedanib
Category
Respiratory Health
Availability
In Stock
Delivery Time
Airmail (14-21 days) | Trackable (5-9 days)
Shipped in a discreet, unmarked envelope with all required documents enclosed.

Product Sheet

Active Ingredient(s)
Nintedanib
Reference Brand
Ofev
Product Origin
Generic Product
Reference Manufacturer
Boehringer Ingelheim
Product Form
Capsule
Regulatory Classification
Rx
Primary Category
COVID-19 Support, Respiratory Health
Product Category
Tyrosine Kinase Inhibitor
Pharmacological Class
Antifibrotic
Manufacturer Description
Formulated for idiopathic pulmonary fibrosis to manage lung scarring and support respiratory function maintenance.
Mechanism of Action
Nintedanib inhibits multiple receptor tyrosine kinases, including PDGF, FGF, and VEGF receptors. This blocks the signaling pathways involved in the proliferation and migration of lung fibroblasts, slowing the progression of fibrosis.
Route of Administration
Oral
Onset Time
4–12 weeks
Duration
12 hours
Contraindications
Pregnancy, Moderate to severe hepatic impairment, Hypersensitivity to nintedanib
Severe Adverse Events
Hepatotoxicity, Arterial thromboembolism, Gastrointestinal perforation — requires immediate medical attention
Common Side Effects
Nausea, Vomiting, Abdominal pain
Uncommon Side Effects
Diarrhea, Weight loss, Elevated liver enzymes
Drug Interactions
Alcohol, Warfarin, Ketoconazole, Rifampin, St. John's Wort
Pregnancy Safety Warnings
FDA Category D: High risk of fetal death or injury. Breastfeeding: Not known if excreted in milk.
Age Restrictions
Safety and efficacy in pediatric patients have not been established.
Storage Guidelines
Store below 25°C away from moisture.
Related Products
Esbriet, Ofev
Information related to Nintedanib is compiled and periodically reviewed with reference to established medical sources and prescribing guidance. Content is provided for general reference and should be confirmed with a registered healthcare professional before use.
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