Utilized for acute gout and familial mediterranean fever to manage inflammatory pain and support joint mobility.
Mechanism of Action
Colchicine binds to tubulin, inhibiting its polymerization into microtubules. This disrupts the chemotaxis and activation of neutrophils at the site of gouty inflammation.
Route of Administration
Oral
Onset Time
12–24 hours
Duration
12–24 hours
Contraindications
Severe renal or hepatic impairment with CYP3A4 inhibitors, Hypersensitivity to colchicine
Severe Adverse Events
Myelosuppression, Rhabdomyolysis, Severe neuropathy — requires immediate medical attention
Information related to Colchicine is compiled and periodically reviewed with reference to established medical sources and prescribing guidance. Content is provided for general reference and should be confirmed with a registered healthcare professional before use.
