Utilized for gastroesophageal reflux disease to alleviate gastric acid production and support stomach health.
Mechanism of Action
Famotidine competitively inhibits histamine at the H2-receptor of the gastric parietal cells. This results in the suppression of both fasting and nocturnal gastric acid secretion as well as secretion stimulated by food.
Route of Administration
Oral
Onset Time
1 hour
Duration
10–12 hours
Contraindications
Hypersensitivity to famotidine, Hypersensitivity to other H2 blockers
Severe Adverse Events
Agranulocytosis, Cardiac arrhythmias, Anaphylaxis — requires immediate medical attention
Common Side Effects
Headache, Dizziness, Constipation
Uncommon Side Effects
Diarrhea, Dry mouth, Nausea
Drug Interactions
Alcohol, Ketoconazole, Warfarin, Atazanavir
Pregnancy Safety Warnings
FDA Category B: No evidence of fetal risk. Breastfeeding: Excreted in milk; compatible with caution.
Age Restrictions
Safety and efficacy established in pediatric patients of all ages; adjust dose by weight.
Information related to Famotidine is compiled and periodically reviewed with reference to established medical sources and prescribing guidance. Content is provided for general reference and should be confirmed with a registered healthcare professional before use.
